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  • Chemistry of Nucleic Acids
    Chemistry of Nucleic Acids

    Life in all its forms is based on nucleic acids which store and transfer genetic information.The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids.The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.

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  • Nucleic Acids in Chemistry and Biology
    Nucleic Acids in Chemistry and Biology

    The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life.Revised, extended, updated and lavishly illustrated, this 4th Edition of Nucleic Acids in Chemistry and Biology is a long-awaited standard text for teaching and research in nucleic acids science.It maintains the close integration of chemistry and biology that characterised the earlier editions and contains a major expansion largely focused on the burgeoning growth of RNA science.Written by an international team of leading experts, all with extensive teaching experience, this 4th Edition provides up-to-date and extended coverage of the reactions and interactions of RNA and DNA with proteins and drugs.A brief history of the discovery of nucleic acids is followed by a molecule-based introduction to the structure and biological roles of DNA and RNA and the basics of Genes and Genomes.New key chapters are devoted to non-coding RNA, nucleic acids sequencing, nucleic acid therapeutics, in vitro evolution and aptamers, and protein-RNA interactions.The text is linked to an extensive list of references to make it a definitive reference source.This authoritative volume presents topics in an integrated manner and readable style with full colour illustrations throughout.It is ideal for graduate and undergraduate students of chemistry and biochemistry, biophysics and biotechnology, and molecular biology and medicine.It will be a guidebook for new researchers to the field of nucleic acids science.

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  • Nucleic Acid-Based Nanomaterials : Stabilities and Applications
    Nucleic Acid-Based Nanomaterials : Stabilities and Applications

    Learn about the cutting-edge nanotechnologies that play an important role in clinical and medical therapies Nucleic acids, the biomolecules that carry most of nature’s critical genetic information, are an omnipresent component of life on earth.Nanomaterials incorporating or otherwise built around nucleic acids and their key properties have a number of clinical and medical applications, including drug delivery and more.Biomaterials scientists and other professionals in these fields can benefit enormously from increased knowledge of these invaluable materials.Nucleic Acid-Based Nanomaterials supplies a thorough, rigorous overview of these materials and their possible applications.Beginning with an introduction to the history of nanomaterials and their nucleic acid-based subcategories, the book offers a detailed and state-of-the-art survey of the current research into these molecules, efforts to increase their biostability, and their incorporation into a range of industries.The result is an essential contribution to materials science in a variety of life-saving contexts.Nucleic Acid-Based Nanomaterials readers will also find: Application-oriented structure that grounds general concepts in their specific instantiationsDetailed discussion of applications including drug delivery, tissue engineering, antimicrobial therapy, and moreA rigorous yet accessible approach suitable for both academia and industry Nucleic Acid-Based Nanomaterials is ideal for chemists of all types, particularly biochemists and medical chemists, and those in industry.

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  • Chemistry and Biology of Non-canonical Nucleic Acids
    Chemistry and Biology of Non-canonical Nucleic Acids

    Discover the fundamentals and intricacies of a subject at the interface of chemistry and biology with this authoritative resource Chemistry and Biology of Non-canonical Nucleic Acids delivers a comprehensive treatment of the chemistry and biology of non-canonical nucleic acids, including their history, structures, stabilities, properties, and functions.You'll learn about the role of these vital compounds in transcription, translation, regulation, telomeres, helicases, cancers, neurodegenerative diseases, therapeutic applications, nanotechnology, and more. An ideal resource for graduate students, researchers in physical, organic, analytical, and inorganic chemistry will learn about uncommon nucleic acids, become the common non-canonical nucleic acids that fascinate and engage academics and professionals in private industry. Split into 15 chapters covering a wide range of aspects of non-canonical nucleic acids, the book explains why these compounds exist at the forefront of a new research revolution at the intersection of chemistry and biology.Chemistry and Biology of Non-canonical Nucleic Acids also covers a broad range of topics critical to understanding these versatile and omnipresent chemicals, including: * A discussion of the dynamic regulation of biosystems by nucleic acids with non-canonical structures * The role played by nucleic acid structures in neurodegenerative diseases and various cancers * An exploration of the future outlook for the chemistry and biology of non-canonical nucleic acids * An introduction to the history of canonical and non-canonical structures of nucleic acids * An analysis of the physicochemical properties of non-canonical nucleic acids Perfect for biochemists, materials scientists, and bioengineers, Chemistry and Biology of Non-canonical Nucleic Acids will also earn a place in the libraries of medicinal and pharmaceutical chemists who wish to improve their understanding of life processes and the role that non-canonical nucleic acids play in them.

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  • What is meant by the term nucleic acid type?

    The term nucleic acid type refers to the specific kind of nucleic acid molecule, which can be either DNA (deoxyribonucleic acid) or RNA (ribonucleic acid). These two types of nucleic acids differ in their structure, function, and location within the cell. DNA is the genetic material that carries the instructions for the development, functioning, growth, and reproduction of all known organisms and many viruses, while RNA is involved in protein synthesis, gene regulation, and other cellular processes. The distinction between DNA and RNA is crucial for understanding the fundamental processes of genetics and molecular biology.

  • How are genetic information passed on as nucleic acids?

    Genetic information is passed on as nucleic acids through the process of DNA replication and cell division. During DNA replication, the double-stranded DNA molecule unwinds and separates into two strands, and each strand serves as a template for the synthesis of a new complementary strand. This results in two identical DNA molecules, each containing one original strand and one newly synthesized strand. During cell division, the replicated DNA is distributed equally between the two daughter cells, ensuring that each cell receives a complete set of genetic information in the form of nucleic acids. This process allows genetic information to be passed on from one generation to the next.

  • How does a single DNA strand look with different nucleic acids?

    A single DNA strand is made up of a sequence of nucleotides, which are the building blocks of DNA. Each nucleotide consists of a sugar molecule, a phosphate group, and a nitrogenous base. There are four different nitrogenous bases in DNA: adenine (A), thymine (T), cytosine (C), and guanine (G). The sequence of these bases along the DNA strand determines the genetic information it carries. So, a single DNA strand can look different depending on the specific arrangement of these nucleic acids along its length.

  • Why was deoxyribonucleic acid also called nucleic acid in the past?

    Deoxyribonucleic acid (DNA) was also called nucleic acid in the past because it was initially discovered as a component of the cell nucleus. At the time of its discovery, scientists were not aware of the full complexity and significance of DNA, and they simply referred to it as a type of nucleic acid. It was later identified as a distinct molecule with its own unique structure and function, leading to the adoption of the name deoxyribonucleic acid to specifically refer to this important genetic material.

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  • Nanotechnology for Nucleic Acid Delivery : Methods and Protocols
    Nanotechnology for Nucleic Acid Delivery : Methods and Protocols

    This detailed second edition volume expands upon the prior edition by addressing newly emerged technologies as well as improved existing protocols in nucleic acid delivery via nanotechnology.The book addresses topics ranging from chemical synthesis of macromolecules and bioconjugates, novel and established nanoformulations, characterization of these nanoformulations for biophysical, biological and toxicological aspects, and also protocols dealing with application and imaging of such carrier systems in vivo.Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective chapters, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and up-to-date, Nanotechnology for Nucleic Acid Delivery: Methods and Protocols, Second Edition serves as an ideal guide to researchers seeking to use this vital area of study in their own lab work or to progress knowledge within the field itself.

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  • Sustainability Challenges of Brazilian Agriculture : Governance, Inclusion, and Innovation
    Sustainability Challenges of Brazilian Agriculture : Governance, Inclusion, and Innovation

    With contributions from a wide range of thematic areas, this book provides a diverse perspective on the contemporary environmental challenges of Brazilian agriculture.Assessing existing experiences of governance interventions, implementation of inclusive and sustainable production practices, as well as technical innovations, this edited volume presents the reader with a nuanced perspective on sustainable future pathways for Brazilian agriculture.In many cases, actors within the agricultural sector stand in a key position to address environmental concerns, which often has generated important breakthroughs and improvement of production practices.Drawing on contributions from authors within a variety of fields, this contribution presents a trans-disciplinary perspective on the problems and pathways through which multi-level interventions can lead to sustainable solutions within the Brazilian agricultural and livestock sector.This book hereby constitutes an informed and timely contribution to the important debates about Brazil’s potential role in confronting environmental problems.More broadly, this volume also sheds light on the process of agricultural transitions in the Global South, and how food security concerns may be reconciled with sustainable production.

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  • Advanced Microbial Technology for Sustainable Agriculture and Environment
    Advanced Microbial Technology for Sustainable Agriculture and Environment

    Advanced Microbial Technology for Sustainable Agriculture and Environment focuses on plant-microbe interactions in respect to bioremediation and plant growth promotion, providing insights on diverse approaches such as genomics, metagenomics, proteomics, bioinformatics and other high-throughput analyses of environmentally relevant microorganisms.The impact of frequent applications of potentially toxic chemicals (pesticides and fertilizers) and increased industrialization processes on microbial diversity emphasizes the potential threat to microbial biodiversity in ecosystems.This is an ideal resource on current trends and the future of PGPR developments with bioremediation potential. Moreover, it gives a deep understanding of the genetics of microbial biodegradation and different remediation mechanisms that help to re-establish the natural environment.

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  • Fashion and Environmental Sustainability : Entrepreneurship, Innovation and Technology
    Fashion and Environmental Sustainability : Entrepreneurship, Innovation and Technology

    The wide range of topics that the book covers are organised into sections reflecting a cradle to grave view of how entrepreneurial, innovative, and tech-savvy approaches can advance environmental sustainability in the fashion sector.These sections include: sustainable materials; innovation in design, range planning and product development; sustainable innovations in fashion supply chains; sustainable innovations in fashion retail and marketing; sustainable alternatives for end-of-life and circular economy initiatives; and more sustainable alternative fashion business models.

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  • What is the composition of the bases in the single strand of nucleic acid?

    The bases in a single strand of nucleic acid are adenine (A), thymine (T), cytosine (C), and guanine (G). Adenine pairs with thymine, and cytosine pairs with guanine in a complementary manner to form the double helix structure of DNA. These base pairs are essential for the genetic information storage and transfer functions of nucleic acids.

  • Why are they called nucleic acids if they are made up of different bases?

    Nucleic acids are called so because they were first discovered in the cell nucleus. They are made up of different bases, but the backbone of the nucleic acid molecule is composed of repeating units of sugar and phosphate, which form a chain. The bases are attached to this sugar-phosphate backbone, and they are responsible for carrying the genetic information. Therefore, the name "nucleic acid" reflects their initial discovery in the cell nucleus and their role in storing and transmitting genetic information.

  • How can sustainability be achieved in livestock farming?

    Sustainability in livestock farming can be achieved through various practices such as rotational grazing to maintain soil health and prevent overgrazing, implementing efficient feed management to reduce waste and improve animal nutrition, and utilizing renewable energy sources to power farm operations. Additionally, reducing the use of antibiotics and hormones, implementing water conservation measures, and promoting animal welfare are also important aspects of sustainable livestock farming. Furthermore, integrating agroforestry and diversifying farm products can contribute to a more sustainable and resilient farming system. Overall, a holistic approach that considers environmental, social, and economic factors is essential for achieving sustainability in livestock farming.

  • How can agriculture be converted to organic farming?

    Converting agriculture to organic farming involves several key steps. First, farmers need to stop using synthetic pesticides, herbicides, and fertilizers and instead use natural alternatives such as compost, manure, and cover crops. They also need to implement crop rotation and diversify their crops to improve soil health and reduce the risk of pests and diseases. Additionally, they should avoid using genetically modified organisms (GMOs) and focus on preserving biodiversity on their farms. Finally, farmers can seek organic certification from a recognized organization to ensure that their products meet the standards of organic farming.

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